INFLUENZA VACCINE

摘要

The present invention relates to monovalent influenza vaccine formulations and vaccination regimes for immunising against influenza disease, their use in medicine, in particular their use in augmenting immune responses to various antigens, and to methods of preparation. In particular, the invention relates to monovalent influenza immunogenic compositions comprising an influenza antigen or antigenic preparation thereof from an influenza virus strain being associated with a pandemic outbreak or having the potential to be associated with a pandemic outbreak, in combination with an oil-in-water emulsion adjuvant comprising a metabolisable oil, a sterol and/or a tocopherol such as alpha tocopherol, and an emulsifying agent.

主权项

1. A method for immunizing a human against influenza virus infection, the method comprising;
selecting a human who was previously vaccinated with a monovalent first vaccine composition comprising a low amount of a influenza virus antigen or antigenic preparation from a first variant of an influenza virus subtype that is associated with a pandemic or that has the potential to be associated with a pandemic, in combination with an adjuvant, wherein the low antigen amount does not exceed 15 μg of HA per dose, and wherein said adjuvant is an oil-in-water emulsion comprising squalene and an emulsifying agent; and administering to the selected human a second vaccine composition comprising an influenza virus antigen or antigenic preparation from a second variant of the same influenza virus subtype.