发明名称 |
Polymorphs of lesopitron dihydrochloride and its hydrated forms, preparation processes and compositions containing it |
摘要 |
PCT No. PCT/ES96/00121 Sec. 371 Date Jan. 21, 1997 Sec. 102(e) Date Jan. 21, 1997 PCT Filed May 29, 1996 PCT Pub. No. WO96/38439 PCT Pub. Date Dec. 5, 1996It comprises the new polymorphs I and II of Lesopitron dihydrochloride, characterized by their infrared spectra and their X-ray diffraction patterns. They are obtained by crystallization of Lesopitron dihydrochloride. It also comprises the forms I-hydrate and II-hydrate, which are obtained from the corresponding polymorphs, which have a water content from 3 to 6% and from 1.5 to 2.5%, respectively. These products are used in human medicine mainly due to their pharmacological activity over the central nervous system.
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申请公布号 |
US5872125(A) |
申请公布日期 |
1999.02.16 |
申请号 |
US19970776113 |
申请日期 |
1997.01.21 |
申请人 |
LABORATORIOS DEL DR. ESTEVE, S.A. |
发明人 |
LUPON-ROSES, PILAR;TOMAS-NAVARRO, JAIME;PUIG-TORRES, SALVADOR;FRIGOLA-CONSTANSA, JORDI |
分类号 |
C07D403/14;A61K31/505;A61K31/506;A61P1/08;A61P25/00;A61P25/22;A61P25/24;A61P25/26;C07D237/00;C07D239/00;C07D295/00;C07D403/12;(IPC1-7):C07D403/14;C07D403/02;A61K31/495 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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