| 摘要 |
The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3′-bipyridin-6′-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer. |
| 申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
HAIDLE, ANDREW, M.;CASH, BRANDON;JEWELL, JAMES, P.;SPENCER, KERRIE;ALTMAN, MICHAEL, D.;OTTE, RYAN, D.;NORTHRUP, ALAN, B. |
