Nucleic acid molecules encoding moonoclonal antibodies speceific for IL17F

摘要

Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

主权项

1. A cDNA molecule encoding a monoclonal anti-interleukin 17F (IL-17F) antibody or an IL-17F binding fragment thereof wherein the antibody comprises in its variable region:
(a) the complementarity determining regions (CDR) of the VH and VL variable region amino acid sequences depicted in
(i) SEQ ID NO:23 (variable heavy chain sequence); and(ii) SEQ ID NO:25 (variable lambda chain sequence); or (b) the amino acid sequence of the VH region depicted in SEQ ID NO: 23 and the VL region depicted in SEQ ID NO: 25.