METHOD OF PRODUCING COMPOSITION COMPRISING HARDLY WATER-SOLUBLE COMPOUND ENCLOSED IN HYDROPHILIC MATRIX AND PREPARATION FOR EXTERNAL USE COMPRISING ANTICANCER AGENT OR DRUG HAVING OCTANOL/WATER PARTITION COEFFICIENT (Log P) OF -3.0 OR MORE BUT NOT MO

摘要

It is intended to provide a method of producing a composition comprising a hardly water soluble compound enclosed in a finely dispersed state in a hydrophilic matrix and a preparation for external use containing an anticancer agent. Namely, a method of producing a composition comprising a hardly water soluble compound enclosed in a hydrophilic matrix which comprises immersing the hydrophilic matrix in an organofluoro compound containing the hardly water soluble compound and thus enclosing the hardly water soluble compound in the hydrophilic matrix; and a preparation for external use containing an anticancer agent which comprises a hydrophilic base having the anticancer agent enclosed therein.