| 摘要 |
Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl. |
| 主权项 |
1. A method of treating a Parkinson's disease caused by abnormal Ire1 activity in a subject in need of such treatment, said method comprising administering to said subject a therapeutically effective amount of a compound having the formula: wherein, R1 is hydrogen,halogen, —CN, —NO, —NO2, —NR9R10, —OR11, —COOR12, —SR13, —COR14, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R9, R10, R11, R12, R13, and R14 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L is —NH—C(O)—NH—; A is aryl or heteroaryl; R37 is halogen, —CN, —CF3, —OH, —NH2, —SO2, —COOH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and w is an integer from 0 to 5. |
