| 摘要 |
In the present invention, there is disclosed a pharmaceutical formulation containing calcium-atorvastatin as active component and pH adjusting substance, wherein the present invention is characterized in that the calcium-atorvastatin is micronized amorphous calcium-atorvastatin and the amount of the pH adjusting substance in the formulation is such that a single administration increases the pH of 900 ml aqueous HC1 solution having a pH of about 3, in particular 900 ml of a 0.001 M HC1 solution, to a pH equal to or greater than pKa+1 or more, and wherein the pH adjusting substance is contained in the pharmaceutical formulation in an amount of 0.2 to 2.0 mmol and said pH adjusting substance is MgO. |
