发明名称 |
METHODS AND COMPOSITIONS INVOLVING EXPRESSION OF a1C SUBUNIT OF L-TYPE CALCIUM CHANNELS IN SMOOTH MUSCLE CELLS |
摘要 |
The present invention concerns methods and composition for modulating the level of gene expression of the a<SUB>1C</SUB> subunit of the L-type calcium channel. Such methods and compositions provide preventative and therapeutic benefits with respect to gastrointestinal motility disorders. In examples of the invention, sustained changes in gene expression of the a<SUB>1C</SUB> subunit are effected by a low dose of a modulator given over an extended period of time. This provides methods and compositions for inducing sustained contractility or relaxation of gut smooth muscle cells. |
申请公布号 |
WO2006091795(A2) |
申请公布日期 |
2006.08.31 |
申请号 |
WO2006US06560 |
申请日期 |
2006.02.24 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;SARNA, SUSHIL, L. |
发明人 |
SARNA, SUSHIL, L. |
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