摘要 |
The invention provides isolated nucleic acid molecules, designated COE-1 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-1 gene has been introduced or disrupted. The invention still further provides isolated COE-1 proteins, fusion proteins, antigenic peptides and anti-COE-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC.;CURTIS, RORY, A., J.;LOGAN, THOMAS, JOSEPH |
发明人 |
CURTIS, RORY, A., J.;LOGAN, THOMAS, JOSEPH |