发明名称 |
ADMINISTRATION OF SERINE PROTEASE INHIBITORS TO THE STOMACH |
摘要 |
The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum. |
申请公布号 |
EP2624823(A4) |
申请公布日期 |
2016.08.03 |
申请号 |
EP20110827628 |
申请日期 |
2011.09.23 |
申请人 |
INFLAMMAGEN;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SCHMID-SCHOENBEIN, GEERT;LEE, ANDREW;WEI, JENG |
分类号 |
A61K31/19;A61K9/08;A61K31/185;A61K31/195;A61K31/24;A61K38/57;A61M25/01;A61P1/00;A61P9/00;A61P25/00 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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