| 发明名称 |
TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING THE ACTIVE SUBSTANCE BUPRENORPHINE |
| 摘要 |
The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and characterized by a considerably increased utilization of the active substance. |
| 申请公布号 |
US2016175447(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201615053139 |
申请日期 |
2016.02.25 |
| 申请人 |
PURDUE PHARMA L.P. |
发明人 |
Hille Thomas;Horstmann Michael;Mueller Walter |
| 分类号 |
A61K47/12;A61K9/70;A61M37/00;A61K31/485 |
主分类号 |
A61K47/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A transdermal therapeutic system for administering buprenorphine to the skin, comprising:
an active-ingredient-impermeable backing layer; at least one pressure-sensitive adhesive matrix layer comprising the active ingredient buprenorphine and at least one carboxylic acid; wherein the matrix layer comprises a polymer selected from polysiloxanes or polyisobutylene; wherein the buprenorphine is dissolved in the at least one carboxylic acid to form a solution and wherein the solution is dispersed, in the form of droplets, in the matrix layer. |
| 地址 |
STAMFORD CT US |
