DETECTION OF MEMBRANE ANDROGEN RECEPTOR (mAR) AGENTS

摘要

Disclosed are methods to detect agents that modulate a membrane androgen receptor (mAR). In one embodiment, the invention provides a method to detect and optionally identify mAR binding ligands. One assay according to the invention detects agents that selectively bind the mAR relative to binding to the classical intracellular androgen receptor (iAR or AR). The invention has a wide spectrum of useful applications including providing a method of screening libraries for chemical entities that preferentially bind the mAR.