发明名称 |
A SEQUENCE OF DSRNA: ATN-RNA, INTERVENTION USING IRNAI, USE OF A SEQUENCE OF DSRNA: ATN-RNA, A METHOD OF TREATING AND INHIBITING A BRAIN TUMOR, A KIT FOR INHIBITING CANCER CELL WHICH EXPRESSES TENASCIN, A METHOD FOR A KIT PREPARATION IN A BRAIN TUMOR THERAPY |
摘要 |
<p>The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied.</p> |
申请公布号 |
EP2121927(A2) |
申请公布日期 |
2009.11.25 |
申请号 |
EP20070793958 |
申请日期 |
2007.07.30 |
申请人 |
INSTYTUT CHEMII BIOORGANICZNEJ PAN;BIOINFOBANK SP. Z O.O.;UNIWERSYTET MEDYCZNY IM. KAROLA MARCINKOWSKIEGO |
发明人 |
BARCISZEWSKI, JAN;BARCISZEWSKA, MIROSLAWA;RYCHLEWSKI, LESZEK;WYSZKO, ELIZA;GAWRONSKA, IWONA;ZUKIEL, RYSZARD;ROLLE, KATARZYNA;NOWAK, STANISAW |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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