COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF TUBERCULOSIS

摘要

Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.

主权项

1. An immunotherapeutic composition comprising:
a) a yeast vehicle; and b) a fusion protein comprising at least one TB antigen, wherein the at least one TB antigen is from a TB protein selected from: Rv0125, Rv1196, Rv1411 (Rv1411c), Rv1738, Rv1813, Rv1909 (Rv1909c), Rv2032, Rv2359, Rv2608, Rv2660, Rv2711, Rv3130, Rv3619, Rv3620, Rv3841, Ag85A, Ag85B, TB10.4 and ESAT-6.