| 摘要 |
PROBLEM TO BE SOLVED: To provide improved dual specificity antibody fusion proteins which can be produced recombinantly and are capable of simultaneously binding two antigens, specifically, two distinct/different antigens.SOLUTION: The present invention provides a multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, where the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilized by a disulfide bond.SELECTED DRAWING: Figure 2B |
