| 发明名称 |
METHYL {(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-DIFLUORO-4-[4-(4-FLUOROPHENYL)PIPERIDIN-1-YL]PHENYL}-5-(6-FLUORO-2-{(2S)-1-[N-(METHOXYCARBONYL)-O-METHYL-L-THREONYL]PYRROLIDIN-2-yl}-1H-BENZIMIDAZOL-5-YL)PYRROLIDIN-2-YL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}PYRROLIDIN-1-YL]-3-METHOXY-1-OXOBUTAN-2-YL}CARBAMATE, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND METHOD OF TREATING HCV INFECTION |
| 摘要 |
A compound, in particular methyl {(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]phenyl}-5-(6-fluoro-2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-threonyl]pyrrolidin-2-yl}-1H-benzimidazol-5-yl)pyrrolidin-2-yl]-6-fluoro-1H-benzimidazol-2-yl}pyrrolidin-1-yl]-3-methoxy-1-oxobutan-2-yl}carbamate, or a pharmaceutically acceptable salt thereof, effective in inhibiting replication of Hepatitis C virus (HCV) is described. This invention also relates to a pharmaceutical composition comprising such compound, and to a method of treating HCV infection. |
| 申请人 |
ABBVIE BAHAMAS LTD. |
发明人 |
DEGOEY DAVID, A.;KATI WARREN, M.;HUTCHINS CHARLES, W.;DONNER PAMELA, L.;KRUEGER ALLAN, C.;RANDOLPH JOHN, T.;MOTTER CHRISTOPHER, E.;NELSON LISSA, T.;PATEL SACHEL, V.;MATULENKO MARK, A.;KEDDY RYAN, G.;JINKERSON TAMMIE, K.;GAO YI;LIU DACHUN;PRATT JOHN, K.;ROCKWAY TODD, W.;MARING CLARENCE, J.;HUTCHINSON DOUGLAS, K.;FLENTGE CHARLES, A.;WAGNER ROLF;TUFANO MICHAEL, D.;BETEBENNER DAVID, A.;SARRIS KATHY;WOLLER KEVIN, R.;WAGAW SEBEL, H.;CALIFANO JEAN, C.;LI WENKE;CASPI DANIEL, D.;BELLIZZI MARY, E.;CARROLL WILLIAM, A. |
