| 摘要 |
PROBLEM TO BE SOLVED: To provide methods and compositions for making a fertile female animal in the F0 generation from a donor male (XY) donor ES cell and a host embryo.SOLUTION: A method for making a fertile female nonhuman animal from an XY donor cell comprises: (a) introducing a nonhuman XY donor cell into a nonhuman host embryo to form a chimeric embryo; and (b) gestating the chimeric embryo to form a nonhuman female animal, where the nonhuman female animal is XY and, upon attaining sexual maturity, is fertile.SELECTED DRAWING: None |
