| 发明名称 |
Method of Enhancing KSHV LANA1 Immunogenicity |
| 摘要 |
An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (“KSHV LANA1”) polypeptide and related methods of eliciting an immune response to KSHV LANA1 are provided. Also described herein is a novel polypeptide capable of inhibiting degradation of a protein or retarding synthesis of a protein when attached to or incorporated within that protein. |
| 申请公布号 |
US2016331833(A1) |
申请公布日期 |
2016.11.17 |
| 申请号 |
US201615179124 |
申请日期 |
2016.06.10 |
| 申请人 |
University of Pittsburgh-Of the Commonwealth System of Higher Education |
发明人 |
Chang Yuan;Moore Patrick S. |
| 分类号 |
A61K39/245;C12N7/00;C07K14/005 |
主分类号 |
A61K39/245 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nucleic acid encoding a Kaposi sarcoma associated herpes virus latency associated nuclear antigen amino acid sequence (“KSHV LANA1”) having the amino acid sequence of SEQ ID NO: 1, wherein the amino acid sequence is modified by the substitution or deletion of at least one amino acid between amino acids 330 and 914. |
| 地址 |
Pittsburgh PA US |
