发明名称 |
6,7-DIHYDRO-5H-PYRAZOLOi1,2-Aö PYRAZOL-1-ONE ZUR KONTROLLE VON ENTZÜNDUNGSFÖRDERNDEN CYTOKINEN |
摘要 |
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula:wherein R comprises ethers or amines;R<1 >is:a) substituted or unsubstituted aryl; orb) substituted or unsubstituted heteroaryl;R<2a >and R<2b >units are each independently hydrogen, ethers, amines, amides, carboxylates, or said units can form a double bond, a carbonyl, or R<2a >and R<2b >can be taken together to form a substituted or unsubstituted ring comprising from 4 to 8 atoms, said ring selected from the group consisting of:i) carbocyclic;ii) heterocyclic;iii) aryl;iv) heteroaryl;v) bicyclic; andvi) heterobicyclic. |
申请公布号 |
DE60218704(D1) |
申请公布日期 |
2007.04.19 |
申请号 |
DE2002618704 |
申请日期 |
2002.09.20 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
CLARK, MICHAEL PHILLIP;LAUFERSWEILER, MATTHEW JOHN;DJUNG, JANE FAR-JINE;NATCHUS, MICHAEL GEORGE;DE, BISWANATH |
分类号 |
C07D487/04;A61K31/4196;A61K31/506;A61K31/5377;A61K31/5517;A61P1/04;A61P7/00;A61P9/00;A61P11/00;A61P19/02;A61P29/00;A61P31/04;A61P43/00;C07D491/113;C07D491/20;C07D495/20 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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