发明名称 |
Cds1 gene-knockout cells and mouse and utilization thereof |
摘要 |
The present inventors established ES cell lines in which one of Cds1 (Chk2) alleles was inactivated by using gene targeting. Chimeric mice were constructed using the cell lines, and genetically modified mice in which both of the Cds1 (Chk2) alleles were inactivated were constructed. Furthermore, by incubating the ES cell lines in which one of Cds1 (Chk2) alleles was inactivated in a selection medium containing a high concentration of an antibiotic, the present inventors constructed mouse ES cell lines in which both the alleles were inactivated. The mice and cells established from the mice can be utilized in screenings for compounds that regulate the cell cycle. |
申请公布号 |
AU7458001(A) |
申请公布日期 |
2002.01.02 |
申请号 |
AU20010074580 |
申请日期 |
2001.06.21 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA;KYOJI IKEDA |
发明人 |
KYOJI IKEDA;NOBORU MOTOYAMA;HIROYUKI TAKAI;MIHO WATANABE |
分类号 |
A01K67/027;A61P35/00;C07K14/47;C12N9/12;C12N15/12 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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