BIOMARKERS RELATED TO ORGAN FUNCTION

摘要

Disclosed herein are methods of identifying biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) that can be used to predict organ or tissue function or dysfunction. In some embodiments, the methods include ex vivo perfusion of the organ or tissue, collection of samples from the organ or tissue (for example, perfusate, fluids produced by the organ (such as bile or urine), or tissue biopsies) and measuring the level of one or more biomarkers in the sample. It is also disclosed herein that an analysis of biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) present in a biological sample from an organ, tissue, or subject can be used to identify whether the organ, tissue, or subject is at risk for (or has) organ dysfunction or organ failure.

主权项

1. A method for identifying an organ or subject as being at risk for organ dysfunction, comprising
determining an amount of one or more biomarkers from a biological sample obtained from the organ or subject, wherein the one or more biomarkers comprise one of those shown in any one of FIGS. 5-7, 10-23, 25, 26, 28, Tables 8 and 9, and/or chemokines and/or cytokines, or any combination thereof; determining whether the amount of the one or more biomarkers differs from an amount of the one or more biomarkers in a control sample or reference value; and identifying the organ or subject as being at risk for organ dysfunction if the amount of the one or more biomarkers differs from the control sample or reference value.