| 发明名称 |
LIPOSOME-BASED IMMUNOTHERAPY |
| 摘要 |
The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease. |
| 申请公布号 |
US2016338953(A1) |
申请公布日期 |
2016.11.24 |
| 申请号 |
US201515111466 |
申请日期 |
2015.01.16 |
| 申请人 |
FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL ;FUNDACIÓ INSTITUT CATALÀ DE NANOCIÈNCIA I NANOTECNOLOGIA ;INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS |
发明人 |
MASPOCH COMAMALA Daniel;CANO SARABIA Antonia María;VIVES PI Marta;PUJOL AUTONELL Irma;VERDAGUER AUTONELL Juan |
| 分类号 |
A61K9/127;A61K39/00 |
主分类号 |
A61K9/127 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A liposome encapsulating an autoantigen, wherein
(i) the liposome has a size comprised from 500 to 15000 nm; and (ii) the liposome membrane comprises phosphatidylserine (PS) in an amount comprised from 10% to 40% by weight with respect to the total membrane liposomal composition. |
| 地址 |
Badalona ES |
