| 摘要 |
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable salt or prodrug, optionally in a pharmaceutically acceptable diluent or excipient. |
| 主权项 |
1. A method for treating a host infected with Epstein-Barr virus or KHSV comprising administering an effective amount of a compound of the general formula (III)or a pharmaceutically acceptable salt or prodrug thereof,wherein
i) X is O, S, NR4, CH2, CHF, or CF2, ii) R1 is chosen from haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, CN, CF3, N3, NO2, aryl, heteroaryl, heteroaryl, acyl or COR5 where R5 is chosen from one of H, OH, SH, alkyl, aminoalkyl, alkoxy, or thioalkyl; iii) R2 and R2′ are independently H; carbonyl substituted with an alkyl, alkenyl, alkynyl, or aryl; benzyl, wherein the phenyl group is optionally substituted with one or more substituents; phosphate; phosphate ester; sulfonate ester; lipid; amino acid; peptide; cholesterol; or other pharmaceutically acceptable leaving group which, when administered in vivo, is capable of providing a compound wherein one or both of R2 and R2′ is H; and R4 is independently H, acyl, alkyl, alkenyl, alkynyl or cycloalkyl. |
