SUSTAINED RELEASE OF ANTIINFECTIVES

摘要

Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of an effective amount of a liposomal/complexed antiinfective to the patient, wherein the (i) administrated amount is 50% or less of the comparative free drug amount, or (ii) the dosing is once a day or less, or (iii) both.

主权项

1. A liposomal ciprofloxacin formulation comprising ciprofloxacin encapsulated in a liposome, wherein the lipid component of the liposomes comprises cholesterol and a phosphatidylcholine, and the lipid component to ciprofloxacin weight ratio is less than 2.5:1 by weight.