发明名称 |
ANTI-HER3 ANTIBODY-DRUG CONJUGATE |
摘要 |
To provide an antitumor drug having excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. Provided is an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER3 antibody via a linker having a structure represented by the formula: -L1-L2-LP-NH-(CH2)n1-La-(CH2)n2-C(=O)- or -L1-L2-LP- (the anti-HER3 antibody is connected to the terminal of L1, the antitumor compound is connected to the carbonyl group of -(CH2)n2-C(=O)- moiety or the C terminal of LP, with the nitrogen atom of the amino group at position 1 as a connecting position). |
申请公布号 |
SG11201608309P(A) |
申请公布日期 |
2016.11.29 |
申请号 |
SG11201608309P |
申请日期 |
2015.04.10 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED;U3 PHARMA GMBH |
发明人 |
HETTMANN, THORE;ABRAHAM, REIMAR;BLUM, SABINE;UENO, SUGURU |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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