发明名称 |
PROTEASOME INHIBITORS AND USES THEREOF |
摘要 |
A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors. |
申请公布号 |
US2016166582(A1) |
申请公布日期 |
2016.06.16 |
申请号 |
US201615050502 |
申请日期 |
2016.02.23 |
申请人 |
Yeda Research and Development Co. Ltd. |
发明人 |
LAVELIN Irina;ROTTER Varda;OREN Moshe;NAVON Ami;KAM Zvi;GEIGER Benjamin |
分类号 |
A61K31/555;G01N33/50;C07K14/47;A61K31/522;A61K31/47 |
主分类号 |
A61K31/555 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a disease in which inhibiting of a proteasome is advantageous, the method comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of NSC321206, NSC310551, NSC99671 and NSC3907, thereby treating the disease. |
地址 |
Rehovot IL |