Oligomeric compounds and compositions for use in modulation of small non-coding RNAS

摘要

Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.

主权项

1. A method of mimicking miR-16 in a cell comprising contacting the cell with a compound comprising a first oligomeric compound and a second oligomeric compound, wherein:
a) the first oligomeric compound consists of 15 to 30 monomeric subunits and is at least 90% identical to the sequence of miR-16 (SEQ ID NO: 196); and b) the second oligomeric compound consists of 15 to 30 monomeric subunits and is complementary to the first oligomeric compound, and c) at least one monomeric subunit of the second oligomeric compound is a modified nucleoside.