LIBRARIES DISPLAYING HUMAN ANTIBODY FRAGMENTS WITH HYBRID COMPLEMENTARITY DETERMINING REGIONS
摘要
Libraries displaying human antibodies (<i>i.e.</i>, whole antibody-like molecules and antigen binding fragments thereof) having nonhuman complementary determining regions are provided. Methods of obtaining human antibodies that recognize self antigens and using such libraries are described.
申请公布号
WO0200005(A1)
申请公布日期
2002.01.03
申请号
WO2001US19502
申请日期
2001.06.18
申请人
ALEXION PHARMACEUTICALS, INC.;ROTHER, RUSSELL;FODOR, WILLIAM, L.;SQUINTO, STEPHEN, P.
发明人
ROTHER, RUSSELL;FODOR, WILLIAM, L.;SQUINTO, STEPHEN, P.
