发明名称 |
METHODS OF TREATING LUPUS BASED ON ANTIBODY AFFINITY AND SCREENING METHODS AND COMPOSITIONS FOR USE THEREOF |
摘要 |
The invention provides methods identifying individuals suitable for treatment for lupus and methods of monitoring treatment, based on measuring antibody affinities, as well as of treating lupus based on measuring antibody affinities. The treatment entails administration of a conjugate comprising a non-immunogenic valency platform molecule and at least two double stranded DNA epitopes, such as DNA molecules, which bind to anti-DNA antibodies from the patient.
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申请公布号 |
WO0141813(A3) |
申请公布日期 |
2002.01.03 |
申请号 |
WO2000US42307 |
申请日期 |
2000.11.28 |
申请人 |
LA JOLLA PHARMACEUTICAL COMPANY;LINNIK, MATTHEW, D.;MCNEELEY, PATRICIA, A. |
发明人 |
LINNIK, MATTHEW, D.;MCNEELEY, PATRICIA, A. |
分类号 |
G01N33/564;A61K38/11;A61K47/48;A61K48/00;A61P13/12;A61P37/02;C12N15/00;G01N33/15;G01N33/50;(IPC1-7):A61K47/48 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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