Novel methods and compositions involving trk tyrosine kinase inhibitors and antineoplastic agents

摘要

Novel methods and compositions comprising antineoplastic agents and trk tyrosine kinase inhibitors are disclosed. In preferred embodiments, the antineoplastic agents comprise nucleoside analogs, and the trk tyrosine kinase inhibitors comprise indolocarbazoles and indenocarbazoles. The methods and compositions may be suitable for the treatment of cancer, particularly pancreatic cancer.