NUCLEAR STRESS RESPONSE IN MOTOR NEURON DISEASE AND OTHER NEUROLOGICAL DISEASES

摘要

The invention relates to diagnosis, prognosis and treatment of neurological diseases. In one embodiment, the present invention provides methods and kits that diagnose whether a subject has a neurological disease or susceptibility to a neurological disease by evaluating nuclear stress body (NSB) levels. Further described are methods and kits that prognose a neurological disease in a subject by monitoring changes in NSB levels. Also described are methods and kits that treat neurological diseases by administering one or more inhibitors of NSB signaling to a patient, as well as compositions containing one or more NSB signaling inhibitors. Medical conditions suitable with various embodiments of the invention include but are not limited to ALS, FTLD, dementia and AD.

主权项

1. A method for diagnosing whether a subject has neurological disease, comprising:
obtaining a biological sample from the subject; determining a level of nuclear stress bodies (NSBs) or determining the presence of nuclear stress bodies (NSBs) in the biological sample; and diagnosing the subject as having neurological disease if the level of NSBs in the biological sample is determined to be higher than a normal subject or if NSBs are determined to be present in the biological sample.