Mandelic acid condensation polymers

摘要

Disclosed herein are compounds and compositions useful for reducing the risk of infection. In particular, disclosed herein are mandelic acid condensation polymers, compositions comprising such compounds, processes for producing such compounds, and methods of using such compounds.

主权项

1. A polymer comprising a distribution of compounds of formula (I) or a pharmaceutically acceptable salt, ester, amide, or prodrug form thereof, wherein R1, R2, and R3 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycle, heteroaryl, aryl, and counterion; R4 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycle, heteroaryl, and aryl; R5, R6, and R7 are each independently selected from the group consisting of alkyl, alkoxy, and halogen; n is an integer greater than zero; x, y, and z are each an integer independently selected from the group consisting of 0, 1, 2, 3, and 4;and wherein the polymer is produced by a process comprising:
cooling a strong acid to a temperature below 0° C. in the absence of solvent; adding mandelic acid or a mandelic acid derivative to the strong acid; and isolating the polymer.