发明名称 |
TREATMENT OF MULTIPLE SCLEROSIS (MS) WITH CAMPATH-1H |
摘要 |
A method for treatment of multiple sclerosis (MS) with Campath-1H with significant efficacy and a favourable safety profile is described, which offers an acceptable benefit/risk ratio. Especially described is the use of Campath-1H (alemtuzumab) for the production of a medicament for the treatment of multiple sclerosis (MS), comprising a first treatment cycle followed by at least one further treatment cycle of Campath-1H (alemtuzumab), in which each treatment cycle comprises 1-5 daily doses which are applied on consecutive days, wherein the daily dose is >0 and = 12 mg, and wherein each treatment cycle is separated from the next cycle by at least 1 - 24 months. Also described are treatment regimens comprising the administration of less than 12 mg/day of Campath-1H for a period of 1-5 consecutive days. |
申请公布号 |
WO2008031626(A1) |
申请公布日期 |
2008.03.20 |
申请号 |
WO2007EP08084 |
申请日期 |
2007.09.11 |
申请人 |
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT;GENZYME CORPORATION;SACHSE, ANDREAS;MARGOLIN, DAVID, HARRIS |
发明人 |
SACHSE, ANDREAS;MARGOLIN, DAVID, HARRIS |
分类号 |
A61K39/395;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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