METHODS OF DETERMINING SUSCEPTIBILITY OF CELLS TO REOVIRUS INFECTION AND METHODS FOR TREATING CELLULAR PROLIFERATIVE DISORDERS WITH REOVIRUS

摘要

Methods for determining susceptibility of cells to reovirus infection are disclosed in which a sample of a cell or cells is provided, the sample is infected with reovirus, a characteristic of the reovirus or the cells, such as uncoating of reo viral coat proteins during entry of reovirus into the cell, infectivity of progeny reovirus obtained from the cell, or number of plaque forming units of reovirus obtained from the cell together with the level of apoptosis in the infected cell in the presence and absence of an apoptosis inhibitor, is measured, and the characteristic of the cells or reovirus is compared to that of a control cell, a controlled susceptible cell, or control reovirus Methods for treating cellular proliferative disorders with reovirus are also disclosed.