Methods and Apparatus for Electronic Stimulation of Tissues Using Signals That Minimize the Effects of Tissue Impedance

摘要

Methods are disclosed for stimulating targeted regions of a brain to alleviate symptoms, treat conditions and/or modify brain activities associated with central sensitivity in a subject. The methods may include selecting a subject suffering from central sensitivity, identifying regions of the brain involved in central sensitivity, and stimulating one or more of these regions of the brain.

主权项

1. A method for providing external electrical stimulation and treatment for a disorder by electrically stimulating and treating neurological tissue of a region of a subject's brain, the method comprising:
generating an amplitude-modulated pulse-width modulated (AMPWM) signal, the AMPWM signal including a high frequency signal component and a low frequency signal component, in which the high frequency signal component is amplitude-modulated and pulse-width modulated and has a sufficiently high frequency to enable the AMPWM signal to penetrate high impedance portions of tissues located between an electrode and neurological tissue to be stimulated, in which the low frequency signal component is of sufficiently low frequency to provide the electrical stimulation and treatment; and transmitting the AMPWM signal from a neurostimulation device via the electrode to the neurological tissue to be stimulated.