| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an article of manufacture comprising a substantially non-immunogenic soft tissue xenograft for implantation into humans. <P>SOLUTION: The invention provides methods for preparing a soft tissue xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the method. The invention further provides a soft tissue xenograft for implantation into a human including a portion of a soft tissue from a non-human animal, wherein the portion has extracellular components and substantially only just dead cells. The extracellular components have reduced proteoglycan molecules. Each of the xenografts is substantially non-immunogenic and has substantially the same mechanical properties as a corresponding native soft tissue. <P>COPYRIGHT: (C)2012,JPO&INPIT |
