FILM COATED PELLETS

摘要

The invention relates to film coated pellets comprising an active ingredient having a high solubility in water. The invention also relates to methods of preparing said pellets and to cores comprising the active ingredient having a high solubility in water and to pharmaceutical compositions comprising the film coated pellets.

主权项

1. A method for the preparation of starter pellets comprising an active pharmaceutical ingredient having a solubility in water at 25° C. of between 100 mg per gram of water to 10 gram per gram of water comprising the steps of:
(1) preparing a powder mixture comprising compacted API seeds and one or more pharmaceutical excipients; (2) preparing a spraying solution comprising an active pharmaceutical ingredient having a solubility in water at 25° C. between 100 mg per gram of water to 10 gram per gram of water and a solvent; (3) spraying the solution of step (2) on the powder mixture obtained in step (1) to obtain starter pellets.