Modulators of miR-323-3p for the prevention or treatment of rheumatoid arthritis

摘要

A miR-323-3p inhibitor is provided for the prevention or therapy of rheumatoid arthritis, comprising a sequence capable of forming a hybrid to miR-323-3p as an oligonucleotide or a vector from which such oligonucleotide is transcribed, or as a miRNA decoy or sponge.

主权项

1. A method for treating rheumatoid arthritis in a patient in need thereof, comprising administering to the patient a miR-323-3p inhibitor comprising a hybridizing sequence of nucleotides at least 90% identical to reverse complementary sequence of SEQ ID 1 or SEQ ID 2; thereby treating the rheumatoid arthritis.