ALPHA AMINOACID ESTER-DRUG CONJUGATES HYDROLYSABLE BY CARBOXYLESTERASE
摘要
Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator.
申请公布号
WO2006117567(A3)
申请公布日期
2007.08.30
申请号
WO2006GB01635
申请日期
2006.05.04
申请人
CHROMA THERAPEUTICS LTD;DAVIDSON, ALAN, HORNSBY;DRUMMOND, ALAN, HASTINGS;NEEDHAM, LINDSEY, ANN
发明人
DAVIDSON, ALAN, HORNSBY;DRUMMOND, ALAN, HASTINGS;NEEDHAM, LINDSEY, ANN