摘要 |
The present invention provides a flowable composition suitable for use as a controlled release implant. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a cell-cycle dependent biological agent, a schedule-dependent biological agent, a metabolite thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides a method of treating cancer in a mammal. The present invention also provides a method of blocking, impeding, or otherwise interfering with cell cycle progression at the G1-phase, G1/S interphase, S-phase, G2/M interface or M-phase of the cell cycle in a mammal. The methods includes administering to a mammal an effective amount of a flowable composition of the present invention. |
申请人 |
ATRIX LABORATORIES, INC.;WARREN, STEPHEN, L.;DADEY, ERIC, J.;ZHOU, MINGXING;DUNN, RICHARD, L. |
发明人 |
WARREN, STEPHEN, L.;DADEY, ERIC, J.;ZHOU, MINGXING;DUNN, RICHARD, L. |