AROMATIC DI-ACID-CONTAINING POLY (ESTER AMIDE) POLYMERS AND METHODS OF USE

摘要

The present invention provides biodegradable, biocompatible aromatic di-acid- containing poly(ester amide) (PEA) polymers with thermo-mechanical properties that can be readily tailored by selection of various combinations and proportions of the di-acid residues in the polymers. The polymers are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The polymer compositions and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.