SPATIAL FREQUENCY DOMAIN IMAGING USING CUSTOM PATTERNS

摘要

The present invention relates to optical devices and methods of extracting optical properties, and depth and fluorescence information for visualizing samples. In one embodiment, the present invention provides a multi-frequency synthesis and extraction (MSE) method for quantitative tissue imaging. In another embodiment, the present invention provides a method of obtaining optical properties and depth information by illuminating a sample with binary square wave patterns of light, wherein a series of spatial frequency components are simultaneously attenuated and can be extracted. In another embodiment, the present invention provides an optical imaging apparatus comprising a Spatial Frequency Domain Imaging (SFDI) device modified to condense frequency information content into a single charged coupled device (CCD) frame, multi-pixel and/or single-pixel sensor using frequency-synthesized patterns.

主权项

1. A method of obtaining optical data from a sample, comprising:
illuminating a sample with multi-frequency patterns having arbitrary spatial frequency intensities; and extracting one or more images of multiple spatial frequency components.