| 摘要 |
ENDO180 is a recycling endocytic receptor that directs bound ligands to degradation in the endosomes. The present invention provides, inter-alia, isolation of an anti-ENDO180 antibody (and fragments thereof) that is internalized into a cell upon binding ENDO180 on the cell surface, and is further capable of internalizing moieties conjugated to the antibody. According to some embodiments, the present invention further provides identification of the antibody (i.e., E3-8D8 deposited with the BCCM with Accession Number LMBP 7203CB), conjugates of the antibody with a moiety, compositions of the antibody with a nanoparticle comprising a moiety and use of the antibody, conjugate or composition for delivery of the moiety into an ENDO180 expressing cell. According to some embodiments, the invention provides the ENDO180 antibody for use in treatment of cancer, fibrosis and macrophage-associated disease. |
