Corticotropin Releasing Factor-binding protein (CRF-BP) is produced recombinantly and is useful for modulating the biological activity of CRF. CRF-BP or fragments thereof and/or antibodies to the proteins are employed in diagnostic assays to determine the levels of CRF, CRF-BP and the ratio of CRF/CRF-BP in a vascular fluid sample. Following such an assay, CRF-BP can be effectively employed to treat pregnancy-related pathological disorders by lowering the ratio of CRF/CRF-BP to within a normal range for pregnancy. The anti-CRF-BP antibodies are also useful to purify the CRF-BP and to modulate the biological effect of CRF-BPs.
申请公布号
CA2147875(A1)
申请公布日期
1994.05.11
申请号
CA19932147875
申请日期
1993.10.25
申请人
SALK INSTITUTE FOR BIOLOGICAL STUDIES (THE);UNIVERSITY OF READING
发明人
POTTER, ELLEN;BEHAN, DOMINIC P.;FISHER, WOLFGANG H.;LINTON, ELIZABETH;LOWRY, PHILIP J.;VALE, WYLIE, WALKER JR.