AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF OPIOID INDUCED DYSFUNCTIONS

摘要

The disclosure provides a method to prevent, control, and/or treat opioid induced dysfunctions comprising administering to a patient in need a guanylate cyclase receptor agonist (GCRA) peptide. Compositions comprising guanylate cyclase receptor agonist (GCRA) peptides, methods of making, and methods of treatment are also disclosed. Further disclosed are the guanylate cyclase receptor agonist (GCRA) peptide and opioid formulated in the same composition.

主权项

1. A method for preventing, treating a condition, or alleviating a symptom of an opioid induced dysfunction comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a guanylate cyclase receptor agonist (GCRA) peptide consisting essentially of the amino acid sequence of any one of Tables 2-8.