| 摘要 |
The invention relates to the compounds having the depicted formulas or pharmaceutically acceptable salts thereof, and well as to the pharmaceutical compositions containing these compounds and pharmaceutically acceptable diluent or carrier. The compounds of the present invention are useful for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), kinesthesia, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, Charcot-Vulpian disease, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, cancer diseases mediated, dependent on, or associated with p110δ activity, including but not restricted to leukaemias, such as acute myeloid leukaemia (AML), myelo-dysplastic syndrome (MDS), myelo-proliferative diseases (MPD), chronic myeloid leukemia (CML), T-cell acute lymphoblastic leukaemia (T-ALL), B-cell acute lymphoblastic leukaemia (B-ALL), non Hodgkins lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer. |
