发明名称 |
Modulators of actin |
摘要 |
The invention provides methods and compositions which find use, inter alia, for modulating the stabilization of actin filaments. The compositions may comprise one or more polypeptide moieties derived from a novel human diaphanous polypeptide and/or one or more nucleic acid moieties derived from a novel human diaphanous gene or gene transcript. The invention also provides agents which specifically modify the binding of a natural human diaphanous gene or gene product with a natural binding target thereof, isolated human diaphanous hybridization probes and primers capable of specifically hybridizing with the disclosed human diaphanous genes, human diaphanous-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
|
申请公布号 |
US5985574(A) |
申请公布日期 |
1999.11.16 |
申请号 |
US19980080897 |
申请日期 |
1998.05.18 |
申请人 |
THE UNIVERSITY OF WASHINGTON;THE UNIVERSITY OF COSTA RICA |
发明人 |
KING, MARY-CLAIRE;LYNCH, ERIC D.;LEE, MING K.;MORROW, JAN E.;WELCSH, PIRI L.;LEON, PEDRO E. |
分类号 |
C07K14/47;(IPC1-7):C12Q1/00;C12P21/06;C12P19/42;C07K16/00 |
主分类号 |
C07K14/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|