| 摘要 |
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R<SUP>1 </SUP>is hydrogen, hydroxy, C<SUB>1-6</SUB>alkyl or aryl; R<SUP>2 </SUP>is hydrogen; optionally substituted C<SUB>1-12</SUB>alkyl; C<SUB>3-7</SUB>cycloalkyl; C<SUB>2-8</SUB>alkenyl, optionally substituted pyrrolidinyl or aryl; R<SUP>3 </SUP>is hydrogen, optionally substituted C<SUB>1-6</SUB>alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.
|
