| 发明名称 |
HEAT-INDUCED RADIOCHEMICAL LABELING OF AN IRON OXIDE NANOPARTICLE |
| 摘要 |
A method of synthesizing a radiolabeled nanoparticle. The method includes heating a solution including an iron oxide nanoparticle and at least one radioactive metal ion to bind the iron oxide nanoparticle and the at least one radioactive metal ion, thereby forming the radiolabeled nanoparticle. The method further includes adding a quenching agent to the solution to complex with non-bound radioactive metal ions remaining in the solution. The method further includes separating the complexed quenching agent from the radiolabeled nanoparticle. |
| 申请公布号 |
US2016256581(A1) |
申请公布日期 |
2016.09.08 |
| 申请号 |
US201415027927 |
申请日期 |
2014.10.09 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
Holland Jason Philip;Josephson Lee |
| 分类号 |
A61K51/12 |
主分类号 |
A61K51/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of synthesizing a radiolabeled nanoparticle, the method comprising:
(i) heating a solution including an iron oxide nanoparticle and at least one radioactive metal ion to bind the iron oxide nanoparticle and the at least one radioactive metal ion, thereby forming the radiolabeled nanoparticle; (ii) adding a quenching agent to the solution to complex with non-bound radioactive metal ions remaining in the solution; and (iii) separating the complexed quenching agent from the radiolabeled nanoparticle. |
| 地址 |
Boston MA US |
