SEROTONIN-TRANSPORT-PROTEIN BINDING RADIOPHARMACEUTICAL FOR THE PRODUCTION OF A DIAGNOSTIC MEDICAMENT FOR THE DIAGNOSIS OF HEADACHE

摘要

The present invention relates to the use of radiopharmaceuticals which specifically bind the serotonin-transport-protein (SERT) for the production of a diagnostic drug for the diagnosis of headache. The radiopharmaceuticals are tracers, which have the capacity to specifically bind the Serotonin-Transport-Protein in the context of a Positron-Emission-Tomography (PET) or a Single Photon Emission Tomography (SPECT). The present invention further relates to a screening method for identifying substances, which selectively modify the binding of these radiopharmaceuticals to the serotonin transporter. These substances are, e.g. precursors of putative therapeutics for the treatment of headache.